Gas6 molecular weight

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August undefined, 2024

WebMar 23, 2024 · Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively referred to as TAM), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggreg …

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WebAnti-GAS6 Antibody detects endogenous levels of total GAS6 protein. Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein, that has a molecular weight of 75kDa. It is located on human chromosome 13q34. WebApr 29, 2024 · Figure 1 shows the ROC curve referred to baseline Gas6 levels: considering an area under the curve of 0.653, we identified a Gas6 level of 58.0 ng/ml as the cut-off predicting a more severe disease evolution (53.33% sensitivity and 77.57% specificity), with a likelihood ratio of 2.38 (IQR: 1.46-3.87). Figure 1 fafsa can\u0027t yet access my irs returns

Molecular insights of Gas6/TAM in cancer development and …

WebGas6, which is maximally expressed at stage VI, may encode an autocrine factor for Sertoli cells because they express GAS6 receptors and respond to this cytokine with increased … WebCalculated molecular weight: 678 aa, 75 kDa: Observed molecular weight: 75 kDa: GenBank accession number: BC038984: Gene symbol: GAS6: … WebNov 4, 2024 · Although full-length AXL contains 894 amino acids and encodes a predicted protein of 98 kDa, the actual observed molecular weight ranges from 100 to 140 kDa … fafsa change dependency status

GAS6 Induces Axl-mediated Chemotaxis of Vascular Smooth …

Molecular insights of Gas6/TAM in cancer development and therapy

WebMar 23, 2024 · Gas6 is a 75 kDa secreted protein with a Gla domain at the N terminus that, based on its structure, belongs to the VKD protein family. 10 The Gla domain is generated by VKD γ -carboxylation of a... WebJul 1, 2024 · GAS6 (growth arrest–specific gene-6) promotes PAR1 (protease-activated receptor-1)–dependent thrombin signaling to induce CCL2 (CC-chemokine ligand 2) expression in the flow-restricted inferior … dog friendly cottages lincolnWebSep 15, 2024 · Axl binds to a high affinity ligand growth arrest specific 6 (Gas6) that belongs to the vitamin K-dependent family of proteins. The Gas6/Axl signaling pathway has been implicated to promote progression, metastasis, immune evasion, and therapeutic resistance in many cancer types. fafsa change of circumstance form

"WebGAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human … " - Gas6 molecular weight

Gas6 molecular weight

Molecular insights of Gas6/TAM in cancer development and therapy

WebOct 4, 2016 · For GAS6 kinetics upon AXL inhibition, cells were serum-starved overnight and preincubated with GI 50 non-Mes or GI 50 Mes concentrations of R428 for an hour, … WebDepositor: Clinical Proteomics Technologies for Cancer. Host Species: rabbit. Antigen Sequence: Positive Tested Species Reactivity: Human. Depositors Institution: National Cancer Institute. Antigen Molecular Weight: 98.3 kDa. Depositors Notes: AXLp is the receptor for growth factor GAS6. AXLp is also a host cell viral receptor.

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WebJun 18, 2024 · Although the molecular weight of the full-length Axl is 104 kDa, post-translational modifications of the extracellular domains give rise to two modified forms … WebAnti-GAS 6 antibody (ab136249) Datasheet SDS Reviews ( 3) Submit a question References (4) Key features and details Rabbit polyclonal to GAS 6 Suitable for: WB Reacts with: Human Isotype: IgG You may also be …

WebMar 31, 2024 · Restoring Gas6 expression overcomes the stress-induced inhibition of HFSC activation and hair growth. ... the cellular and molecular mechanisms by which corticosterone regulates tissue ... WebJan 18, 2024 · Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological …

WebMar 23, 2024 · Background knowledge of Gas6. Gas6 is a 75 kDa secreted protein with a Gla domain at the N terminus that, based on its structure, belongs to the VKD protein family. 10 The Gla domain is generated by VKD γ-carboxylation of a cluster of Glu residues and is believed to be involved in intramolecular and intermolecular protein–protein or … Web康朗生物为您提供硫胺素酶thtpa抗体的参数及2024年最新报价，厂家专业的硫胺素酶thtpa抗体售后服务团队，是您值得信赖的 ...

WebMonoclonal Antibody for studying GAS6. Cited in 14 publications. Validated for WB, IHC, IF. Highly specific and rigorously validated in-house, GAS6 (D3A3G) Rabbit Monoclonal Antibody (CST #67202) is ready to ship. ...

WebMar 8, 2024 · TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poor … fafsa challenge ctWebApr 10, 2024 · Activation of AXL Receptor and its ligand GAS6 is a major mechanism of acquired resistance to EGFR-TKIs therapy ... Moreover, due to its relatively large molecular weight, the concentration of drug in tumors is limited. Study suggested only a small portion of ADCs could reach to the tumor cells. fafsa changes 2023 24Web1. Mass from volume & concentration Concentration: Formula Weight (daltons): Volume: Mass = 2. Volume from mass & concentration Mass: Formula Weight (daltons): Concentration: 3. Molarity from mass & volume Mass: Formula Weight (daltons): Volume: Molarity = 4. Dilute a stock solution Stock concentration: Desired concentration: Desired … fafsa can\u0027t link to irsWebJul 28, 2024 · Flow cytometry analysis of the indicated surface molecules on SKO-007(J3) pLKO.1-GAS6 shRNA or pLKO.1-Control (n=3). A representative experiment is shown (B, left panel). Histograms represent the MFI of specific mAb subtracted of MFI of isotype control. Data are shown as mean ± SD (*P< 0.05; Mann-Whitney) (B, right panel). dog friendly cottages keswickWebMar 9, 2024 · These findings suggested that low expression of GAS6-AS1 might exert an essential role in AFST through downregulating its downstream target mRNAs GOLGA8A and BACH2, and GAS6-AS1 might be a potential target for AFST therapy. dog friendly cottages lincolnshire coastWebJan 11, 2006 · The crystal structure at 3.3 A resolution of a minimal human Gas6/Axl complex reveals an assembly of 2:2 stoichiometry, in which the two immunoglobulin-like domains of the Axl ectodomain are crosslinked by the first laminin G-like domain of Gas6, with no direct Axl/Axl or Gas6/Gas6 contacts. fafsa changes 2022 2023WebGas6 is present at around 0.2 nM (18 ng mL−1) in normal human serum or plasma [4], whereas the anticoagulant protein S is present at a thousand-fold higher concentration [5]. Gas6 binds and activates the three members of the TAM-family of receptor tyrosine kinases comprising Tyro3, Axl and Mer [6,7]. dog friendly cottages lake district uk