List of lysosomotropic agents
WebThe compounds that accumulate in lysosomes are classified as lysosomotropic agents. Roshan Ashoor, Rolla Yafawi, Bart Jessen, Shuyan Lu, 'The Contribution of … WebLysosomal exocytosis is also perturbed in a variety of lysosomal and lipid storage disorders (reviewed in Samie and Xu, 2014;Settembre and Ballabio, 2014), and lysosomal exocytosis can drive the...
List of lysosomotropic agents
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WebRoles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation Tomoki Kuwaharaa,⁎, Kai Funakawaa, Tadayuki Komoria, Maria Sakuraia, Gen Yoshiia, Tomoya Eguchia,b, Mitsunori... WebLysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents Amines whose pK values lie between about 5 and 9 are lysosomotropic because …
WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4.
Web10 mrt. 2024 · Pharmaceutical lysosomotropic agents include the antidepressants siramesine, nortriptyline, desipramine, imipramine, and clomipramine [ 19 ]. These have shown effectiveness in breast cancer, colon cancer, and CLL cells. Antimalarials mefloquine and chloroquine have shown effectiveness in breast cancer, lymphoma, and leukemia … WebDownload Table LogP and pKa values and molecular structures of the lysosomotropic drugs used in this work from publication: Lysosomal accumulation of anticancer drugs …
Web19 okt. 2024 · Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in individuals receiving long term drug treatment.Experimental …
Web22 nov. 2013 · It is well documented that lysosomotropic agents can trigger lysosomal membrane permeabilization [52,53]. We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting … cinema tickets richmondWeb1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine and amitriptyline; the antipsychotic, chlorpromazine; and the selective serotonin re-uptake inhibitor, fluoxetine [50]. diablo 3 slash commandsWeb9 sep. 2024 · May 2024 · Methods in molecular biology (Clifton, N.J.) Tomoki Kuwahara. Leucine-rich repeat kinase 2 (LRRK2) is a causative gene product of autosomal-dominant Parkinson’s disease and has been ... cinema tickets tastecardWebWidely Available Lysosomotropic Agents Should Be Considered as a Potential Therapy for COVID-19 Jan Homolak * and Ivan Kodvanj Version 1 : Received: 21 March 2024 / … diablo 3 single player cheatsWebThe use of lysosomotropic agents offers a new treatment possibility since they disrupt lysosomal membranes and can trigger a series of events leading to cell death. In addition, combining lysosome disrupting agents with targeted inhibitors can … cinema tickets spidermanWeb9 feb. 2024 · Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and … cinema tickets spider man no way homeWebWith the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria … cinema tickets to print